Slow light for deep tissue imaging with ultrasound modulation.
نویسندگان
چکیده
Slow light has been extensively studied for applications ranging from optical delay lines to single photon quantum storage. Here, we show that the time delay of slow-light significantly improves the performance of the narrowband spectral filters needed to optically detect ultrasound from deep inside highly scattering tissue. We demonstrate this capability with a 9 cm thick tissue phantom, having 10 cm(-1) reduced scattering coefficient, and achieve an unprecedented background-free signal. Based on the data, we project real time imaging at video rates in even thicker phantoms and possibly deep enough into real tissue for clinical applications like early cancer detection.
منابع مشابه
Gold nanoparticle-induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor-bearing mice
Introduction: Light-driven cancer therapy strategies (e.g. photodynamic therapy and photothermal therapy) have undergone remarkable progress in recent years, but they still suffer from a serious drawback of limited penetration depth of light in tissue. As a non-invasive and non- ionizing radiation, ultrasound can be focused remotely, transferring acoustic energy deep in the bo...
متن کاملEngineering of core/shell nanoparticles surface plasmon for increasing of light penetration depth in tissue (modeling and analysis)
Objectives: In this article, a new procedure for increasing the light penetration depth in a tissue is studied and simulated. It has been reported that the most important problem in biomedical optical imaging relates to the light penetration depth, and so this makes a dramatic restriction on its applications. In the optical imaging method, the detection of the backscattered pho...
متن کاملUltrasound-Modulated Fluorescent Contrast Agent for Optical Detection of Cancer Lesions in Deep Tissue
Optical imaging in a highly scattering medium is effective only at very shallow depths which limits its use as a diagnostic tool in biomedical imaging, particularly for tumor detection. By combining optical and acoustic modalities, high-contrast, tumor state-relevant optical information at higher spatial resolutions can be achieved. Hybrid imaging modalities such as acousto-optic and photoacous...
متن کاملQuantitative Comparison of Analytical solution and Finite Element Method for investigation of Near-Infrared Light Propagation in Brain Tissue Model
Introduction: Functional Near-Infrared Spectroscopy (fNIRS) is an imaging method in which light source and detector are installed on the head; consequently, re-emission of light from human skin contains information about cerebral hemodynamic alteration. The spatial probability distribution profile of photons penetrating tissue at a source spot, scattering into the tissue, and being released at ...
متن کاملHigh resolution imaging beyond the acoustic diffraction limit in deep tissue via ultrasound-switchable NIR fluorescence
Fluorescence imaging in deep tissue with high spatial resolution is highly desirable because it can provide details about tissue's structural, functional, and molecular information. Unfortunately, current fluorescence imaging techniques are limited either in penetration depth (microscopy) or spatial resolution (diffuse light based imaging) as a result of strong light scattering in deep tissue. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Applied physics letters
دوره 100 13 شماره
صفحات -
تاریخ انتشار 2012